PICALM anticorps (C-Term)

N° du produit ABIN2774386

Détail du produit anti-PICALM anticorps

Antigène: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PICALM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: DLDSSLANLV GNLGIGNGTT KNDVNWSQPG EKKLTGGSNW QPKVAPTTAW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against PICALM. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 551 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PICALM

Antigène: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Autre désignation: PICALM (PICALM Produits)

Synonymes: anticorps LAP-3, anticorps PEPS, anticorps CALM, anticorps CLTH, anticorps LAP, anticorps PAP180, anticorps fit-1, anticorps fit1, anticorps mKIAA4114, anticorps Calm, anticorps leucine aminopeptidase 3, anticorps phosphatidylinositol binding clathrin assembly protein, anticorps si:ch211-200p22.4, anticorps LAP3, anticorps PICALM, anticorps Picalm, anticorps si:ch211-200p22.4

Sujet: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.
Alias Symbols: CALM, CLTH, LAP
Protein Interaction Partner: UBC, PELI2, VCAM1, ITGA4, FN1, SIRT1, ILF3, EGFR, EEF1A1, DNM2, CD55, ABCC2, ATP6V1E1, AP2A1, SH3GLB2, FLOT1, HNRNPDL, SEC24D, SEC24C, ATP6V1F, HIP1R, LAMTOR3, ITSN1, EHD2, CASP8, CLTCL1, CASP3, PLCG1, DDIT3, CLTC,
Protein Size: 551

Poids moléculaire: 60 kDa

ID gène: 8301

NCBI Accession: NM_001206947, NP_001193876

UniProt: E9PN05

Pathways: Synaptic Membrane