TPSB2 anticorps (Middle Region)

N° du produit ABIN2774583

Détail du produit anti-TPSB2 anticorps

Antigène: TPSB2 (Tryptase beta 2 (TPSB2))

Épitope: Middle Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPSB2 est non-conjugé

Application: Western Blotting (WB)

Séquence: QALQRVGIVG GQEAPRSKWP WQVSLRVHGP YWMHFCGGSL IHPQWVLTAA

Homologie: Human: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against TPSB2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TPSB2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TPSB2

Antigène: TPSB2 (Tryptase beta 2 (TPSB2))

Autre désignation: TPSB2 (TPSB2 Produits)

Synonymes: anticorps TPS2, anticorps tryptaseB, anticorps tryptaseC, anticorps Mcpt6, anticorps tryptase beta 2 (gene/pseudogene), anticorps tryptase beta 2, anticorps TPSB2, anticorps Tpsb2

Sujet: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Alias Symbols: TPS2, tryptaseB, tryptaseC
Protein Size: 282

Poids moléculaire: 31 kDa

ID gène: 64499

NCBI Accession: NM_003294, NP_003285

UniProt: P20231