FBXO2 anticorps (C-Term)

N° du produit ABIN2774692

Cet anticorps anti-FBXO2 est un anticorps Lapin Polyclonal détectant FBXO2 dans WB. Adapté pour Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio) et Lapin.

Aperçu rapide pour FBXO2 anticorps (C-Term) (ABIN2774692)

Antigène: FBXO2 (F-Box Protein 2 (FBXO2))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FBXO2 anticorps

Épitope: C-Term

Séquence: LAEFATGQVA VPEDGSWMEI SHTFIDYGPG VRFVRFEHGG QDSVYWKGWF

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against Fbxo2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 297 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur FBXO2

Antigène: FBXO2 (F-Box Protein 2 (FBXO2))

Autre désignation: Fbxo2

Sujet: Fbxo2 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Alias Symbols: FBG1, FBX2, Fbs1, Fbs2, MGC54895, NFB42, Prpl4
Protein Interaction Partner: Stat1, Cul1, Skp1a, Bace1, Vcp,
Protein Size: 297

Poids moléculaire: 34 kDa

ID gène: 230904

NCBI Accession: NM_176848, NP_789818

UniProt: Q80UW2