MKRN1 anticorps (N-Term)

N° du produit ABIN2774707

Détail du produit anti-MKRN1 anticorps

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Épitope: N-Term

Reactivité: Humain, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Rat, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKRN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MKRN1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 147 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MKRN1

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Autre désignation: MKRN1 (MKRN1 Produits)

Synonymes: anticorps MKRN1, anticorps MGC84269, anticorps mkrn1, anticorps Makorin-1, anticorps RNF61, anticorps RFP, anticorps makorin ring finger protein 1, anticorps E3 ubiquitin-protein ligase makorin-1, anticorps makorin ring finger protein 1 S homeolog, anticorps makorin, ring finger protein, 1, anticorps MKRN1, anticorps LOC100393879, anticorps mkrn1.S, anticorps Mkrn1

Sujet: The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Alias Symbols: FLJ21334, RNF61
Protein Interaction Partner: UBC, TP53, CDKN1A, FADD, MAP1LC3B, UBE2W, DUSP23, CSNK1G1, UBE2D3, TERT, EXOSC8,
Protein Size: 147

Poids moléculaire: 16 kDa

ID gène: 23608

NCBI Accession: NM_003338, NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding