MKRN1 anticorps (N-Term)

N° du produit ABIN2774707

Cet anticorps Lapin Polyclonal détecte spécifiquement MKRN1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Chien, Cobaye, Cheval, Boeuf (Vache), Rat, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour MKRN1 anticorps (N-Term) (ABIN2774707)

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Reactivité: Humain, Souris, Chien, Cobaye, Cheval, Boeuf (Vache), Rat, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKRN1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MKRN1 anticorps

Épitope: N-Term

Fonction: MKRN1 Antibody - N-terminal region

Séquence: GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MKRN1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104798

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MKRN1

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Autre désignation: MKRN1

Sujet:

Background Information: The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

Gene Name: Makorin ring finger protein 1

Alternative Symbols: RNF61

Protein Name: E3 ubiquitin-protein ligase makorin-1

Poids moléculaire: 16kDa

ID gène: 23608

NCBI Accession: NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding