HERC5 anticorps (N-Term)

N° du produit ABIN2774738

Détail du produit anti-HERC5 anticorps

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Épitope: N-Term

Reactivité: Humain, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HERC5 est non-conjugé

Application: Western Blotting (WB)

Séquence: CLVAELVGYR VTQIACGRWH TLAYVSDLGK VFSFGSGKDG QLGNGGTRDQ

Homologie: Cow: 86%, Dog: 79%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HERC5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HERC5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1024 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HERC5

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Autre désignation: HERC5 (HERC5 Produits)

Synonymes: anticorps HERC5, anticorps CEB1, anticorps CEBP1, anticorps HECT and RLD domain containing E3 ubiquitin protein ligase 5, anticorps hect domain and RLD 5, anticorps HERC5

Sujet: HERC5 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Alias Symbols: CEB1, CEBP1
Protein Interaction Partner: UBC, SMAD4, UBE2D1, gag, ISG15, TXNRD1, IRF3, HSPA8, CTNNB1, HERC5, SIRT7, STK38, PITX2, ERCC2, CCND1, CCNE1, CCNB1, CCNA2, NME2, CDKN1A,
Protein Size: 1024

Poids moléculaire: 117 kDa

ID gène: 51191

NCBI Accession: NM_016323, NP_057407

UniProt: Q9UII4