RNF31 anticorps (Middle Region)

N° du produit ABIN2774753

Cité dans 8 publications. Cet anticorps anti-RNF31 Polyclonal Lapin (ABIN2774753) détecte spécifiquement RNF31 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval et Boeuf (Vache).

Aperçu rapide pour RNF31 anticorps (Middle Region) (ABIN2774753)

Antigène: RNF31 (Ring Finger Protein 31 (RNF31))

Reactivité: Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF31 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RNF31 anticorps

Épitope: Middle Region

Fonction: RNF31 Antibody - middle region

Séquence: SLINAHSLDP ATLYEVEELE TATERYLHVR PQPLAGEDPP AYQARLLQKL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RNF31. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RNF31

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43241-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RNF31 (ABIN2774753)

Shibata, Tokunaga, Goto, Komatsu, Gohda, Saeki, Tanaka, Takahashi, Sawasaki, Inoue, Oshiumi, Seya, Nakano, Tanaka, Iwai, Inoue: "HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains." dans: PLoS pathogens, Vol. 13, Issue 1, pp. e1006162, (2017) (PubMed).

Lafont, Kantari-Mimoun, Draber, De Miguel, Hartwig, Reichert, Kupka, Shimizu, Taraborrelli, Spit, Sprick, Walczak: "The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death." dans: The EMBO journal, Vol. 36, Issue 9, pp. 1147-1166, (2017) (PubMed).

Kupka, De Miguel, Draber, Martino, Surinova, Rittinger, Walczak: "SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes." dans: Cell reports, Vol. 16, Issue 9, pp. 2271-80, (2016) (PubMed).

Queisser, Dada, Deiss-Yehiely, Angulo, Zhou, Kouri, Knab, Liu, Stegh, DeCamp, Budinger, Chandel, Ciechanover, Iwai, Sznajder: "HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth." dans: American journal of respiratory and critical care medicine, Vol. 190, Issue 6, pp. 688-98, (2014) (PubMed).

Blackwell, Zhang, Workman, Ting, Iwai, Habelhah: "Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed I?B kinase activation." dans: Molecular and cellular biology, Vol. 33, Issue 10, pp. 1901-15, (2013) (PubMed).

Liu, Chen, Cai, Wu, Chen, Wu, Sun, Chen: "MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades." dans: eLife, Vol. 2, pp. e00785, (2013) (PubMed).

Smit, Monteferrario, Noordermeer, van Dijk, van der Reijden, Sixma: "The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension." dans: The EMBO journal, Vol. 31, Issue 19, pp. 3833-44, (2012) (PubMed).

Sieber, Lange, Kollmorgen, Erhardt, Quaas, Gontarewicz, Sass, Tiegs, Kreienkamp: "Sharpin contributes to TNF? dependent NF?B activation and anti-apoptotic signalling in hepatocytes." dans: PLoS ONE, Vol. 7, Issue 1, pp. e29993, (2012) (PubMed).

Détails sur RNF31

Antigène: RNF31 (Ring Finger Protein 31 (RNF31))

Autre désignation: RNF31

Sujet:

Background Information: PWP2 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

Gene Name: Ring finger protein 31

Alternative Symbols: HOIP, Paul, ZIBRA

Protein Name: E3 ubiquitin-protein ligase RNF31

Poids moléculaire: 120kDa

ID gène: 55072

NCBI Accession: NP_060469

UniProt: Q96EP0