GJB2 anticorps (Middle Region)

N° du produit ABIN2774858

Détail du produit anti-GJB2 anticorps

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GJB2 est non-conjugé

Application: Western Blotting (WB)

Séquence: STPALLVAMH VAYRRHEKKR KFIKGEIKSE FKDIEEIKTQ KVRIEGSLWW

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 93%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against GJB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human GJB2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 226 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GJB2

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Autre désignation: GJB2 (GJB2 Produits)

Synonymes: anticorps ppk, anticorps cx26, anticorps dfna3, anticorps dfnb1, anticorps nsrd1, anticorps dfna3a, anticorps dfnb1a, anticorps MGC53062, anticorps connexin-26, anticorps GJB2, anticorps AI325222, anticorps Cnx26, anticorps Cx26, anticorps Gjb-2, anticorps CXN-26, anticorps CX26, anticorps DFNA3, anticorps DFNA3A, anticorps DFNB1, anticorps DFNB1A, anticorps HID, anticorps KID, anticorps NSRD1, anticorps PPK, anticorps gap junction protein beta 2 L homeolog, anticorps gap junction protein beta 2, anticorps gap junction protein, beta 2, anticorps gjb2.L, anticorps GJB2, anticorps Gjb2

Sujet: Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 (MIM 121014) is designated alpha-1 gap junction protein, whereas CX32 (GJB1, MIM 304040) and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43.
Alias Symbols: HID, KID, PPK, CX26, DFNA3, DFNB1, NSRD1, DFNA3A, DFNB1A
Protein Interaction Partner: CD14, CNST, FBXO2, SKP1, UBC, GJB6, CAV1, GJB1,
Protein Size: 226

Poids moléculaire: 25 kDa

ID gène: 2706

NCBI Accession: NM_004004, NP_003995

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization