PPP2R3B anticorps (C-Term)

N° du produit ABIN2775379

Cet anticorps anti-PPP2R3B est un anticorps Lapin Polyclonal détectant PPP2R3B dans WB. Adapté pour Humain, Souris, Chien, Boeuf (Vache), Rat, Poisson zèbre (Danio rerio), Cobaye, Cheval et Lapin. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour PPP2R3B anticorps (C-Term) (ABIN2775379)

Antigène: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Reactivité: Humain, Souris, Chien, Boeuf (Vache), Rat, Poisson zèbre (Danio rerio), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP2R3B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PPP2R3B anticorps

Épitope: C-Term

Séquence: TFFNIEKYLD HEQKEQISLL RDGDSGGPEL SDWEKYAAEE YDILVAEETA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 77%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 77%, Rat: 82%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against PPP2R3B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PPP2R3B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 575 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PPP2R3B (ABIN2775379)

van Kempen, Redpath, Elchebly, Klein, Papadakis, Wilmott, Scolyer, Edqvist, Pontén, Schadendorf, van Rijk, Michiels, Dumay, Helbling-Leclerc, Dessen, Wouters, Stass, Greenwood, Ghanem, van den Oord et al.: "The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene. ..." dans: Science translational medicine, Vol. 8, Issue 369, pp. 369ra177, (2016) (PubMed).

Détails sur PPP2R3B

Antigène: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Autre désignation: PPP2R3B

Sujet: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. PPP2R3B belongs to the B'' family. The B'' family has been further divided into subfamilies. PPP2R3B belongs to the beta subfamily of regulatory subunit B''.Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: NY-REN-8, PPP2R3L, PPP2R3LY, PR48, NYREN8
Protein Interaction Partner: DUSP12, UBC, PPP2R1A, CDC6, PPP2R1B, PPP2CA,
Protein Size: 575

Poids moléculaire: 65 kDa

ID gène: 28227

NCBI Accession: NM_013239, NP_037371

UniProt: Q9Y5P8

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases