CEMIP2 (Middle Region) anticorps

N° du produit ABIN2775385

Cet anticorps Lapin Polyclonal détecte spécifiquement CEMIP2 dans WB. Il présente une réactivité avec des échantillons de Boeuf (Vache), Chien, Cheval, Humain, Souris, Porc, Lapin, Rat et Cobaye.Il a été cité dans 1 publication.

Aperçu rapide pour CEMIP2 (Middle Region) anticorps (ABIN2775385)

Antigène: CEMIP2

Reactivité: Boeuf (Vache), Chien, Cheval, Humain, Souris, Porc, Lapin, Rat, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Détail du produit

Épitope: Middle Region

Fonction: CEMIP2 Antibody - middle region

Séquence: MLTGLCQGCG TRQVVFTSDP HKSYLPVQFQ SPDKAETQRG DPSVISVNGT

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TMEM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TMEM2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42382-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Référence

Zhu, Xie, Li, Huang, Zhao, Hu, Wang, Gu, Gao, Peng: "TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway." dans: Cell death & disease, Vol. 7, Issue 6, pp. e2239, (2016) (PubMed).

Détail du antigène

Antigène: CEMIP2

Sujet:

Background Information: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Gene Name: cell migration inducing hyaluronidase 2

Alternative Symbols: TMEM2

Protein Name: cell surface hyaluronidase

Poids moléculaire: 154 kDa

ID gène: 23670

NCBI Accession: NP_037522

UniProt: Q9UHN6