COX IV anticorps (N-Term)

N° du produit ABIN2775574

Il existe 3+ publications pour ce produit. L’anticorps anti-COX IV Polyclonal Lapin est utilisé pour la détection de COX IV dans des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval et Lapin. Il a été validé pour WB, IHC et IP.

Aperçu rapide pour COX IV anticorps (N-Term) (ABIN2775574)

Antigène: COX IV (COX4I1) (Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COX IV est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-COX IV anticorps

Épitope: N-Term

Fonction: COX4I1 Antibody - N-terminal region

Séquence: AISTSVCVRA HESVVKSEDF SLPAYMDRRD HPLPEVAHVK HLSASQKALK

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 85%, Rabbit: 86%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against COX4I1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COX4I1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8098330

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-COX IV (ABIN2775574)

Hwang, Dornbos, Steidemann, Dunivin, Rizzo, LaPres: "Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome." dans: Toxicology and applied pharmacology, (2016) (PubMed).

Geerling, Boon, van der Zon, van den Berg, van den Hoek, Lombès, Princen, Havekes, Rensen, Guigas: "Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice." dans: Diabetes, Vol. 63, Issue 3, pp. 880-91, (2014) (PubMed).

Snyder, Wang, Patton, Arosio, Levi, Earley, Allen, Connor: "Mitochondrial ferritin in the substantia nigra in restless legs syndrome." dans: Journal of neuropathology and experimental neurology, Vol. 68, Issue 11, pp. 1193-9, (2009) (PubMed).

Détails sur COX IV

Antigène: COX IV (COX4I1) (Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1))

Autre désignation: COX4I1

Sujet:

Targeted Subunit: 4 isoform 1, mitochondrial

Background Information: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX4I1 is the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme.Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.

Gene Name: Cytochrome c oxidase subunit IV isoform 1

Alternative Symbols: COX4, COXIV, COX4-1, COXIV-1, MC4DN16, COX IV-1

Protein Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Poids moléculaire: 19kDa

ID gène: 1327

NCBI Accession: NP_001852

UniProt: P13073

Pathways: Proton Transport