LIN7C anticorps (N-Term)

N° du produit ABIN2775625

Détail du produit anti-LIN7C anticorps

Antigène: LIN7C (Lin-7 Homolog C (LIN7C))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIN7C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against LIN7C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human LIN7C

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 197 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LIN7C

Antigène: LIN7C (Lin-7 Homolog C (LIN7C))

Autre désignation: LIN7C (LIN7C Produits)

Synonymes: anticorps LIN7C, anticorps fb75b09, anticorps wu:fb75b09, anticorps zgc:101881, anticorps LIN-7-C, anticorps LIN-7C, anticorps MALS-3, anticorps MALS3, anticorps VELI3, anticorps 9130007B12Rik, anticorps AI303698, anticorps AU019331, anticorps AW125731, anticorps D2Ertd520e, anticorps Veli3, anticorps lin-7 homolog C, crumbs cell polarity complex component, anticorps lin-7 homolog C L homeolog, anticorps lin-7 homolog C (C. elegans), anticorps LIN7C, anticorps lin7c.L, anticorps lin7c, anticorps Lin7c

Sujet: LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Alias Symbols: FLJ11215, LIN-7-C, LIN-7C, MALS-3, VELI3, MALS3
Protein Interaction Partner: UBC, AMOTL2, LATS2, YAP1, Wwtr1, CFTR, ELAVL1, AMOT, UIMC1, SPATA2, KCNJ12, BAIAP2, ABCA1, HTR2C, CASK, KCNJ4, DLG1, APBA1,
Protein Size: 197

Poids moléculaire: 22 kDa

ID gène: 55327

NCBI Accession: NM_018362, NP_060832

UniProt: Q9NUP9

Pathways: Synaptic Membrane