CBX1 anticorps (N-Term)

N° du produit ABIN2775787

Détail du produit anti-CBX1 anticorps

Antigène: CBX1 (Chromobox Homolog 1 (CBX1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Lapin, Cheval, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CBX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CBX1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 185 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CBX1 (ABIN2775787)

Ayoub, Jeyasekharan, Bernal, Venkitaraman: "HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response." dans: Nature, Vol. 453, Issue 7195, pp. 682-6, (2008) (PubMed).

Détails sur CBX1

Antigène: CBX1 (Chromobox Homolog 1 (CBX1))

Autre désignation: CBX1 (CBX1 Produits)

Synonymes: anticorps CBX, anticorps HP1-BETA, anticorps HP1Hs-beta, anticorps HP1Hsbeta, anticorps M31, anticorps MOD1, anticorps p25beta, anticorps Cbx, anticorps Cbx-rs2, anticorps E430007M08Rik, anticorps HP1B, anticorps Hp1beta, anticorps cbx1, anticorps wu:fe14b09, anticorps zgc:55739, anticorps zgc:86924, anticorps chromobox 1, anticorps chromobox homolog 1a (HP1 beta homolog Drosophila), anticorps chromobox 1 S homeolog, anticorps chromobox homolog 1b (HP1 beta homolog Drosophila), anticorps CBX1, anticorps Cbx1, anticorps cbx1a, anticorps cbx1.S, anticorps cbx1b

Sujet: CBX1 is the component of heterochromatin. CBX1 recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. CBX1 interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the in
Alias Symbols: CBX, HP1-BETA, HP1Hs-beta, M31, MOD1, p25beta, HP1Hsbeta
Protein Interaction Partner: PRDM6, SUMO1, UBC, RNF2, PARK2, NR2F6, VHL, EHMT2, ABI3BP, VTN, TRIM39, CBX5, HIST1H3B, KLF11, HIST3H3, PCNA, MECP2, ADNP, POGZ, ADNP2, CBX3, TRIM28, CHAF1A, HIST1H4F, XRCC6, CHD4, H2AFB1, NSL1, SUMO2, HIST1H3A, Mad2l2, Cbx1, DNMT3B, ZNF382, H3F3A, SUV420
Protein Size: 185

Poids moléculaire: 21 kDa

ID gène: 10951

NCBI Accession: NM_006807, NP_006798

UniProt: P83916