DMP1 anticorps (N-Term)

N° du produit ABIN2775904

Il existe 1 publication pour ce produit. L’anticorps anti-DMP1 Polyclonal Lapin est utilisé pour la détection de DMP1 dans des échantillons de Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache) et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour DMP1 anticorps (N-Term) (ABIN2775904)

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache), Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DMP1 anticorps

Épitope: N-Term

Fonction: DMTF1 Antibody - N-terminal region

Séquence: LRMYDDRNHV GKYTPEEIEK LKELRIKHGN DWATIGAALG RSASSVKDRC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DMTF1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34603-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-DMP1 (ABIN2775904)

Tschan, Gullberg, Shan, Torbett, Fey, Tobler: "The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias." dans: Leukemia, Vol. 22, Issue 5, pp. 1087-90, (2008) (PubMed).

Détails sur DMP1

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Autre désignation: DMTF1

Sujet:

Background Information: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 35 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: cyclin D binding myb like transcription factor 1

Alternative Symbols: DMP1, DMTF, MRUL, hDMP1

Protein Name: cyclin-D-binding Myb-like transcription factor 1

Poids moléculaire: 84kDa

ID gène: 9988

NCBI Accession: NP_066968

UniProt: Q9Y222