KLHL12 anticorps (N-Term)

N° du produit ABIN2775905

Cet anticorps Lapin Polyclonal détecte spécifiquement KLHL12 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye et Poisson zèbre (Danio rerio).

Aperçu rapide pour KLHL12 anticorps (N-Term) (ABIN2775905)

Antigène: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLHL12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KLHL12 anticorps

Épitope: N-Term

Séquence: EKGKPYVDIQ GLTASTMEIL LDFVYTETVH VTVENVQELL PAACLLQLKG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against KLHL12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL12

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KLHL12

Antigène: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Autre désignation: KLHL12

Sujet: KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Alias Symbols: C3IP1, DKIR, hDKIR
Protein Interaction Partner: PEF1, TBC1D10C, FGD2, SYNE4, CCBE1, TTBK2, RPP25L, GLYCTK, MRPL10, SNX20, C1QTNF2, ZBP1, KLHL12, WDYHV1, PRR13, CARD10, KLHL3, INMT, CUL3, BAG6, VEGFB, UBE2I, SDCBP, PDGFRB, MPP1, FLNA, TAOK2, DGCR6, DROSHA, EZH2, KLHL2, DVL3, UBC, ATXN1, CAND1, DCUN1D1,
Protein Size: 568

Poids moléculaire: 63 kDa

ID gène: 59349

NCBI Accession: NM_021633, NP_067646

UniProt: Q53G59