KLHL12 anticorps (N-Term)
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- Antigène Voir toutes KLHL12 Anticorps
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cheval, Poisson zèbre (Danio rerio), Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KLHL12 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- EKGKPYVDIQ GLTASTMEIL LDFVYTETVH VTVENVQELL PAACLLQLKG
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against KLHL12. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL12
- Top Product
- Discover our top product KLHL12 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
- Autre désignation
- KLHL12 (KLHL12 Produits)
- Synonymes
- anticorps zgc:92570, anticorps wu:fi60g03, anticorps C3ip1, anticorps C3IP1, anticorps DKIR, anticorps hDKIR, anticorps Ski2 like RNA helicase, anticorps kelch like family member 12 L homeolog, anticorps kelch like family member 12, anticorps kelch-like family member 12, anticorps kelch-like 12, anticorps SKIV2L, anticorps klhl12.L, anticorps KLHL12, anticorps klhl12, anticorps Klhl12
- Sujet
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KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Alias Symbols: C3IP1, DKIR, hDKIR
Protein Interaction Partner: PEF1, TBC1D10C, FGD2, SYNE4, CCBE1, TTBK2, RPP25L, GLYCTK, MRPL10, SNX20, C1QTNF2, ZBP1, KLHL12, WDYHV1, PRR13, CARD10, KLHL3, INMT, CUL3, BAG6, VEGFB, UBE2I, SDCBP, PDGFRB, MPP1, FLNA, TAOK2, DGCR6, DROSHA, EZH2, KLHL2, DVL3, UBC, ATXN1, CAND1, DCUN1D1,
Protein Size: 568 - Poids moléculaire
- 63 kDa
- ID gène
- 59349
- NCBI Accession
- NM_021633, NP_067646
- UniProt
- Q53G59
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