KEAP1 anticorps (C-Term)

N° du produit ABIN2775979

Cité dans 1 publication. Cet anticorps anti-KEAP1 Polyclonal Lapin (ABIN2775979) détecte spécifiquement KEAP1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour KEAP1 anticorps (C-Term) (ABIN2775979)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-KEAP1 anticorps

Épitope: C-Term

Fonction: KEAP1 Antibody - C-terminal region

Séquence: TWTFVAPMKH RRSALGITVH QGRIYVLGGY DGHTFLDSVE CYDPDTDTWS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KEAP1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KEAP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8103731

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KEAP1 (ABIN2775979)

Konishi, Baumgarten, Ishida, Saitoh, Anker, Springer: "Protein levels in Keap1-Nrf2 system in human failing heart." dans: International journal of cardiology, Vol. 225, pp. 62-64, (2016) (PubMed).

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1

Sujet:

Background Information: KEAP1 contains KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Gene Name: Kelch-like ECH-associated protein 1

Alternative Symbols: INrf2, KLHL19

Protein Name: Kelch-like ECH-associated protein 1

Poids moléculaire: 70kDa

ID gène: 9817

NCBI Accession: NP_987096

UniProt: Q14145

Pathways: Maintenance of Protein Location