THRA anticorps (Middle Region)

N° du produit ABIN2776019

Cet anticorps Lapin Polyclonal détecte spécifiquement THRA dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Mouton, Cobaye et Poisson zèbre (Danio rerio) et a été mentionné dans 1 publication.

Aperçu rapide pour THRA anticorps (Middle Region) (ABIN2776019)

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Mouton, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-THRA anticorps

Épitope: Middle Region

Séquence: DQIILLKGCC MEIMSLRAAV RYDPESDTLT LSGEMAVKRE QLKNGGLGVV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against THRA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human THRA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 490 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-THRA (ABIN2776019)

Kiss-Toth, Harlock, Lath, Quertermous, Wilkinson: "A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation." dans: PLoS ONE, Vol. 8, Issue 9, pp. e76034, (2013) (PubMed).

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA

Sujet: The THRA gene encodes a protein that is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone.
Alias Symbols: AR7, EAR7, ERB-T-1, ERBA, ERBA1, MGC000261, MGC43240, NR1A1, THRA1, THRA2, c-ERBA-1, CHNG6
Protein Interaction Partner: L3MBTL3, AMOTL2, RANBP9, NCOR1, PTGES3, THRA, RXRA, FOXJ1, CLIC1, C1D, NCOR2, BUB3, tat, GTF2B, ARID5A, SUMO1, SUMO3, MED1, NRIP1, MED21, CDK7, MED25, RGN, CUL1, SEPP1, TBL1XR1, HDAC3, SMC1A, XRCC5, TBL1X, PRKDC, LIG3, HSPA4, GPS2, XRCC6, PARP1, EMD, GRIP
Protein Size: 490

Poids moléculaire: 55 kDa

ID gène: 7067

NCBI Accession: NM_003250, NP_003241

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development