DMP1 anticorps (Middle Region)

N° du produit ABIN2776044

Cet anticorps Lapin Polyclonal détecte spécifiquement DMP1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache) et Porc.

Aperçu rapide pour DMP1 anticorps (Middle Region) (ABIN2776044)

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DMP1 anticorps

Épitope: Middle Region

Fonction: DMTF1 Antibody - middle region

Séquence: TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DMTF1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34828-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur DMP1

Antigène: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Autre désignation: DMTF1

Sujet:

Background Information: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 35 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: cyclin D binding myb like transcription factor 1

Alternative Symbols: DMP1, DMTF, MRUL, hDMP1

Protein Name: cyclin-D-binding Myb-like transcription factor 1

Poids moléculaire: 84kDa

ID gène: 9988

NCBI Accession: NP_066968

UniProt: Q9Y222