DMP1 anticorps (Middle Region)
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- Antigène Voir toutes DMP1 (DMTF1) Anticorps
- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Chien, Cheval, Lapin, Cobaye, Boeuf (Vache), Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DMP1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human DMTF1
- Top Product
- Discover our top product DMTF1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 760 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
- Autre désignation
- DMTF1 (DMTF1 Produits)
- Synonymes
- anticorps DMP1, anticorps DMTF, anticorps hDMP1, anticorps Dimp, anticorps Dmp1, anticorps DMTF1, anticorps zgc:92448, anticorps cyclin D binding myb like transcription factor 1, anticorps cyclin D binding myb-like transcription factor 1, anticorps DMTF1, anticorps Dmtf1, anticorps dmtf1
- Sujet
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DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of DMTF1 is regulated by binding of D-cyclins. The gene encoding DMTF1 is hemizygously deleted in approximately 40 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
Alias Symbols: DMP1, DMTF, FLJ41265, hDMP1
Protein Interaction Partner: SRA1, TP53, ATF7IP, CCND1, CCND3, CCND2,
Protein Size: 760 - Poids moléculaire
- 84 kDa
- ID gène
- 9988
- NCBI Accession
- NM_021145, NP_066968
- UniProt
- Q9Y222
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