KCNK3 anticorps (C-Term)

N° du produit ABIN2776142

Cet anticorps Lapin Polyclonal détecte spécifiquement KCNK3 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Mouton et Lapin. Il a été cité dans 2+ publications.

Aperçu rapide pour KCNK3 anticorps (C-Term) (ABIN2776142)

Antigène: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Mouton, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KCNK3 anticorps

Épitope: C-Term

Fonction: KCNK3 Antibody - C-terminal region

Séquence: TCVEQSHSSP GGGGRYSDTP SRRCLCSGAP RSAISSVSTG LHSLSTFRGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KCNK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNK3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP35090-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KCNK3 (ABIN2776142)

Donner, Schullenberg, Geduldig, Hüning, Mersmann, Zacharowski, Kovacevic, Decking, Aller, Schmidt: "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability." dans: Basic research in cardiology, Vol. 106, Issue 1, pp. 75-87, (2010) (PubMed).

Nogueira, Gerry, Mantero, Mariniello, Rainey: "The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas." dans: Clinical endocrinology, Vol. 73, Issue 1, pp. 22-9, (2010) (PubMed).

Détails sur KCNK3

Antigène: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Autre désignation: KCNK3

Sujet:

Background Information: KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Gene Name: Potassium channel, subfamily K, member 3

Alternative Symbols: OAT1, PPH4, TASK, TASK1, TBAK1, K2p3.1, TASK-1

Protein Name: Potassium channel subfamily K member 3

Poids moléculaire: 43kDa

ID gène: 3777

NCBI Accession: NP_002237

UniProt: O14649