KCNN3 anticorps (C-Term)

N° du produit ABIN183133

Détail du produit anti-KCNN3 anticorps

Antigène: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNN3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: ITELNDRSED LEKQIGSLES KLEHLTASFN SLPLLIADTL RQQQQQLLSA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KCNN3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 736 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KCNN3

Antigène: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Autre désignation: KCNN3 (KCNN3 Produits)

Synonymes: anticorps KCa2.3, anticorps SK3, anticorps SKCA3, anticorps hSK3, anticorps potassium calcium-activated channel subfamily N member 3, anticorps potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, anticorps Kcnn3, anticorps KCNN3

Sujet: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
Alias Symbols: SK3, hSK3, SKCA3, KCa2.3
Protein Interaction Partner: UBC, RAB5A, DNM2, CAV1, APP, CALM1,
Protein Size: 736

Poids moléculaire: 81 kDa

ID gène: 3782

NCBI Accession: NM_002249, NP_002240

UniProt: Q9UGI6