ZIC2 anticorps (C-Term)

N° du produit ABIN2776475

Cet anticorps anti-ZIC2 est un anticorps Lapin Polyclonal détectant ZIC2 dans WB et IHC. Adapté pour Humain, Rat, Souris et Cobaye. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour ZIC2 anticorps (C-Term) (ABIN2776475)

Antigène: ZIC2

Reactivité: Humain, Rat, Souris, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZIC2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ZIC2 anticorps

Épitope: C-Term

Séquence: EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS

Homologie: Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 532 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ZIC2 (ABIN2776475)

Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." dans: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." dans: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." dans: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." dans: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

Détails sur ZIC2

Antigène: ZIC2

Autre désignation: ZIC2

Sujet: ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Alias Symbols: HPE5
Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
Protein Size: 532

Poids moléculaire: 55 kDa

ID gène: 7546

NCBI Accession: NM_007129, NP_009060

UniProt: O95409

Pathways: Tube Formation