DGCR8 anticorps (N-Term)

N° du produit ABIN2776557

Détail du produit anti-DGCR8 anticorps

Antigène: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DGCR8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: DKKDEENELD QEKRVEYAVL DELEDFTDNL ELDEEGAGGF TAKAIVQRDR

Homologie: Cow: 85%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against DGCR8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 773 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-DGCR8 (ABIN2776557)

Belair, Paikari, Moltzahn, Shenoy, Yau, DallEra, Simko, Benz, Blelloch: "DGCR8 is essential for tumor progression following PTEN loss in the prostate." dans: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).

Van Duyne, Guendel, Klase, Narayanan, Coley, Jaworski, Roman, Popratiloff, Mahieux, Kehn-Hall, Kashanchi: "Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery." dans: PLoS ONE, Vol. 7, Issue 7, pp. e40662, (2012) (PubMed).

Kye, Neveu, Lee, Zhou, Steen, Sahin, Kosik, Silva: "NMDA mediated contextual conditioning changes miRNA expression." dans: PLoS ONE, Vol. 6, Issue 9, pp. e24682, (2011) (PubMed).

Détails sur DGCR8

Antigène: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Autre désignation: DGCR8 (DGCR8 Produits)

Synonymes: anticorps MGC78846, anticorps DGCR8, anticorps gy1, anticorps dgcrk6, anticorps C22orf12, anticorps DGCRK6, anticorps Gy1, anticorps pasha, anticorps D16H22S1742E, anticorps D16H22S788E, anticorps D16Wis2, anticorps N41, anticorps Vo59c07, anticorps si:ch211-106a19.4, anticorps wu:fc23f08, anticorps wu:fc38f06, anticorps DGCR8 microprocessor complex subunit L homeolog, anticorps DiGeorge syndrome critical region gene 8, anticorps DGCR8 microprocessor complex subunit, anticorps DGCR8, microprocessor complex subunit, anticorps microRNA 3618, anticorps dgcr8.L, anticorps DGCR8, anticorps dgcr8, anticorps Dgcr8, anticorps MIR3618

Sujet: DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
Alias Symbols: C22orf12, DGCRK6, Gy1, pasha
Protein Interaction Partner: MEOX2, PYCRL, DROSHA, RAE1, MAPK1, PRMT1, ERH, CDKN2A, BMI1, SRPK2, SRPK1, CDT1, NAT10, PLEK2, RPRD2, MAPRE2, PRPF4, FLII, APP, CUL3, DDX17, HNRNPR, NCL, ILF3, HSPA8, HSPA5, HNRNPU, HNRNPH1, FUS, DHX9, DDX5,
Protein Size: 773

Poids moléculaire: 85 kDa

ID gène: 54487

NCBI Accession: NM_022720, NP_073557

UniProt: Q8WYQ5

Pathways: Regulatory RNA Pathways