EXOSC6 anticorps (N-Term)

N° du produit ABIN2776614

L’anticorps Lapin Polyclonal anti-EXOSC6 a été validé pour WB et IHC. Il convient pour détecter EXOSC6 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache) et Porc.

Aperçu rapide pour EXOSC6 anticorps (N-Term) (ABIN2776614)

Antigène: EXOSC6 (Exosome Component 6 (EXOSC6))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-EXOSC6 anticorps

Épitope: N-Term

Séquence: MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK

Homologie: Cow: 93%, Human: 100%, Mouse: 88%, Pig: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 272 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EXOSC6

Antigène: EXOSC6 (Exosome Component 6 (EXOSC6))

Autre désignation: EXOSC6

Sujet: EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Alias Symbols: p11, EAP4, MTR3, Mtr3p, hMtr3p
Protein Interaction Partner: CEP250, DCP1B, EXOSC6, CHPF, MIF4GD, XRN1, NDUFA13, MRPL4, EXOSC1, MRPS18B, UPF2, RAB3GAP2, SKIV2L2, GSE1, EXOSC7, EXOSC8, ZFP36, TUFM, EXOSC10, MAN2C1, ESRRA, C1QBP, AICDA, DIS3L, EXOSC4, EXOSC3, CUL3, ELAVL1, HDGF, UBC, EXOSC5, DNAJC30, MOCS3, MPP6, EXO
Protein Size: 272

Poids moléculaire: 30 kDa

ID gène: 118460

NCBI Accession: NM_058219, NP_478126

UniProt: Q5RKV6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response