ERI1 anticorps (N-Term)

N° du produit ABIN2776656

Cité dans 1 publication. Cet anticorps anti-ERI1 Polyclonal Lapin (ABIN2776656) détecte spécifiquement ERI1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval et Porc.

Aperçu rapide pour ERI1 anticorps (N-Term) (ABIN2776656)

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERI1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ERI1 anticorps

Épitope: N-Term

Fonction: ERI1 Antibody - N-terminal region

Séquence: SKFITSSASD FSDPVYKEIA ITNGCINRMS KEELRAKLSE FKLETRGVKD

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 85%, Pig: 93%, Rabbit: 100%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against THEX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ERI1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41157-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ERI1 (ABIN2776656)

Kupsco, Wu, Marzluff, Thapar, Duronio: "Genetic and biochemical characterization of Drosophila Snipper: A promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5' exonucleases." dans: RNA (New York, N.Y.), Vol. 12, Issue 12, pp. 2103-17, (2006) (PubMed).

Détails sur ERI1

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Autre désignation: ERI1

Sujet:

Background Information: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Gene Name: exoribonuclease 1

Alternative Symbols: HEXO, THEX1, 3'HEXO

Protein Name: 3'-5' exoribonuclease 1

Poids moléculaire: 349

ID gène: 90459

NCBI Accession: NP_699163

UniProt: Q8IV48