Doublecortin anticorps (C-Term)

N° du produit ABIN2776750

Cet anticorps anti-Doublecortin est un anticorps Lapin Polyclonal détectant Doublecortin dans WB et IHC. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin et Cobaye.

Aperçu rapide pour Doublecortin anticorps (C-Term) (ABIN2776750)

Antigène: Doublecortin (DCX)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Doublecortin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Doublecortin anticorps

Épitope: C-Term

Séquence: PEKFRYAQDD FSLDENECRV MKGNPSATAG PKASPTPQKT SAKSPGPMRR

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DCX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DCX

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 365 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Doublecortin

Antigène: Doublecortin (DCX)

Autre désignation: DCX

Sujet: In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The protein contains two doublecortin domains, which bind microtubules. In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.
Alias Symbols: DBCN, DC, LISX, SCLH, XLIS
Protein Interaction Partner: KIFC3, GOLGA2, TRIM23, KRTAP10-8, KRT40, RINT1, MID2, SPAG5, IKZF1, CALCOCO2, ZBTB5, TRIM27, MEOX1, FBXO25, APP, PPP1R9B, PPP1CA, PAFAH1B1, ACD, TINF2, POT1, TERF1, SPP1, USP9X, NFASC, TRIM39, AP1M1, AP2M1, DCX, CDK5,
Protein Size: 365

Poids moléculaire: 40 kDa

ID gène: 1641

NCBI Accession: NM_178152, NP_835365

UniProt: O43602