Uromodulin anticorps (C-Term)

N° du produit ABIN2776813

Cet anticorps Lapin Polyclonal détecte spécifiquement Uromodulin dans WB. Il présente une réactivité envers Humain, Souris, Chien et Boeuf (Vache).

Aperçu rapide pour Uromodulin anticorps (C-Term) (ABIN2776813)

Antigène: Uromodulin (UMOD)

Reactivité: Humain, Souris, Chien, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Uromodulin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Uromodulin anticorps

Épitope: C-Term

Séquence: PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL

Homologie: Cow: 91%, Dog: 86%, Human: 100%, Mouse: 85%

Attributs du produit: This is a rabbit polyclonal antibody against UMOD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human UMOD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 640 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Autre désignation: UMOD

Sujet: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Alias Symbols: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Protein Interaction Partner: LTA, MMP8,
Protein Size: 640

Poids moléculaire: 67 kDa

ID gène: 7369

NCBI Accession: NM_001008389, NP_001008390

UniProt: P07911