PDZK1 anticorps (N-Term)

N° du produit ABIN2776855

Cet anticorps anti-PDZK1 est un anticorps Lapin Polyclonal détectant PDZK1 dans WB. Adapté pour Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache) et Lapin.

Aperçu rapide pour PDZK1 anticorps (N-Term) (ABIN2776855)

Antigène: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDZK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PDZK1 anticorps

Épitope: N-Term

Séquence: NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PDZK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PDZK1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 519 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PDZK1

Antigène: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Autre désignation: PDZK1

Sujet: PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
Protein Interaction Partner: AKT1, CDC37, Ptgir, ABCC4, CFTR, APP, Klhl17, Syngap1, Dlg4, SLC26A6, SLC22A4, SLCO1A2, SLC15A2, PDZK1IP1, SLC22A11, SLC22A12, AKAP10, SLC22A5, ABCC2, SCARB1, CLCN3, PEX5, ABCA1, SSTR5, SLC17A1, SLC9A3, GFAP, SLC34A3, FARP2, SLK, SLC9A3R1, SLC9A3R2, UBE2I
Protein Size: 519

Poids moléculaire: 57 kDa

ID gène: 5174

NCBI Accession: NM_002614, NP_002605

UniProt: Q5T2W1