ALAD anticorps (N-Term)

N° du produit ABIN2776921

Cité dans 1 publication. Cet anticorps anti-ALAD Polyclonal Lapin (ABIN2776921) détecte spécifiquement ALAD dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour ALAD anticorps (N-Term) (ABIN2776921)

Antigène: ALAD (Aminolevulinate Dehydratase (ALAD))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALAD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALAD anticorps

Épitope: N-Term

Fonction: ALAD Antibody - N-terminal region

Séquence: EEMLRPLVEE GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ALAD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ALAD

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8094532

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ALAD (ABIN2776921)

Tang, Breinig, Stith, Mischel, Tannir, Kokona, Fairman, Jaffe: "Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins)." dans: The Journal of biological chemistry, Vol. 281, Issue 10, pp. 6682-90, (2006) (PubMed).

Détails sur ALAD

Antigène: ALAD (Aminolevulinate Dehydratase (ALAD))

Autre désignation: ALAD

Sujet:

Background Information: The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 Molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway, zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 Molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway, zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: Aminolevulinate dehydratase

Alternative Symbols: PBGS, ALADH

Protein Name: Delta-aminolevulinic acid dehydratase RuleBase RU000515

Poids moléculaire: 39kDa

ID gène: 210

NCBI Accession: NP_001003945

UniProt: Q6ZMU0