FECH anticorps (N-Term)

N° du produit ABIN2776936

Détail du produit anti-FECH anticorps

Antigène: FECH (Ferrochelatase (FECH))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio), Cheval, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FECH est non-conjugé

Application: Western Blotting (WB)

Séquence: LDRDLMTLPI QNKLAPFIAK RRTPKIQEQY RRIGGGSPIK IWTSKQGEGM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 77%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against FECH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human FECH

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 429 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FECH (ABIN2776936)

Miyake, Ishii, Kawashima, Kodama, Sugano, Fujimoto, Hirao: "siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines." dans: Photochemistry and photobiology, Vol. 85, Issue 4, pp. 1020-7, (2009) (PubMed).

Détails sur FECH

Antigène: FECH (Ferrochelatase (FECH))

Autre désignation: FECH (FECH Produits)

Synonymes: anticorps AI894116, anticorps Fcl, anticorps fch, anticorps zgc:109851, anticorps EPP, anticorps FCE, anticorps CG2098, anticorps Dmel\\CG2098, anticorps GB15952, anticorps ferrochelatase L homeolog, anticorps ferrochelatase, anticorps Ferrochelatase, anticorps ferrochelatase, mitochondrial, anticorps ferrochelatase HemH, anticorps ferrochelatase (predicted), anticorps fech.L, anticorps hemH, anticorps Fech, anticorps FECH, anticorps fech, anticorps FeCH, anticorps LOC409922, anticorps hem15, anticorps APH_RS01140

Sujet: Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: EPP, FCE
Protein Interaction Partner: PPP2R1A, UBC, NEDD8, MDM2, FBXO6, gag-pol, COPS5, COPS6, CUL3, ELAVL1, MINOS1, MME, USP42, USP20, ABCB7, FECH,
Protein Size: 429

Poids moléculaire: 47 kDa

ID gène: 2235

NCBI Accession: NM_001012515, NP_001012533

UniProt: Q8NAN0

Pathways: Transition Metal Ion Homeostasis