Amylin/DAP anticorps (N-Term)

N° du produit ABIN2776959

Détail du produit anti-Amylin/DAP anticorps

Antigène: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Épitope: N-Term

Reactivité: Humain, Lapin, Chien, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Amylin/DAP est non-conjugé

Application: Western Blotting (WB)

Séquence: MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV

Homologie: Cow: 82%, Dog: 86%, Horse: 93%, Human: 100%, Rabbit: 86%

Attributs du produit: This is a rabbit polyclonal antibody against IAPP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human IAPP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 89 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Amylin/DAP

Antigène: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Autre désignation: IAPP (IAPP Produits)

Synonymes: anticorps DAP, anticorps IAP, anticorps LOC100230121, anticorps Amylin, anticorps islet amyloid polypeptide, anticorps IAPP, anticorps Iapp

Sujet: Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Alias Symbols: AMYLIN, DAP, IAP
Protein Interaction Partner: COL25A1, RAMP2, RAMP1, PDX1, PCSK2, PCSK1,
Protein Size: 89

Poids moléculaire: 4 kDa

ID gène: 3375

NCBI Accession: NM_000415, NP_000406

UniProt: P10997

Pathways: Hormone Activity, Feeding Behaviour