Coagulation Factor X anticorps (C-Term)

N° du produit ABIN2776973

Détail du produit anti-Coagulation Factor X anticorps

Antigène: Coagulation Factor X (F10)

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Coagulation Factor X est non-conjugé

Application: Western Blotting (WB)

Séquence: STLMTQKTGI VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ

Homologie: Cow: 92%, Dog: 86%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against F10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human F10

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 488 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Coagulation Factor X

Antigène: Coagulation Factor X (F10)

Autre désignation: F10 (F10 Produits)

Synonymes: anticorps FX, anticorps FXA, anticorps Cf10, anticorps fX, anticorps fi12c10, anticorps wu:fi12c10, anticorps F10, anticorps f10, anticorps coagulation factor X, anticorps Coagulation factor X, anticorps coagulation factor 10 L homeolog, anticorps F10, anticorps f10, anticorps CpipJ_CPIJ012712, anticorps CpipJ_CPIJ014863, anticorps CpipJ_CPIJ016937, anticorps CpipJ_CPIJ017791, anticorps fa10, anticorps f10.L

Sujet: F10 is the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting.This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FX, FXA
Protein Interaction Partner: UBC, GAD2, SERPINA10, HIST1H1C, MGST3, PRKAB1, SERPINA5, SERPINB8, F8, F10, F7, F5, PROS1, PLAT, PLG, SERPINB6, TFPI, APOH, GGCX, F3,
Protein Size: 488

Poids moléculaire: 29 kDa

ID gène: 2159

NCBI Accession: NM_000504, NP_000495

UniProt: P00742