APCS anticorps (N-Term)

N° du produit ABIN2777091

Détail du produit anti-APCS anticorps

Antigène: APCS (Amyloid P Component, Serum (APCS))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APCS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT

Homologie: Guinea Pig: 86%, Human: 100%, Mouse: 77%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against APCS. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human APCS

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 223 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-APCS (ABIN2777091)

Veerhuis, Boshuizen, Morbin, Mazzoleni, Hoozemans, Langedijk, Tagliavini, Langeveld, Eikelenboom: "Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q." dans: Neurobiology of disease, Vol. 19, Issue 1-2, pp. 273-82, (2005) (PubMed).

Détails sur APCS

Antigène: APCS (Amyloid P Component, Serum (APCS))

Autre désignation: APCS (APCS Produits)

Synonymes: anticorps PTX2, anticorps SAP, anticorps Sap, anticorps APCS, anticorps FP, anticorps SAP(FP), anticorps apcs, anticorps ptx2, anticorps sap, anticorps amyloid P component, serum, anticorps serum amyloid P-component, anticorps amyloid P component, serum protein L homeolog, anticorps APCS, anticorps Apcs, anticorps apcs.L

Sujet: APCS is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. This gene has multiple polyadenylation sites.
Alias Symbols: MGC88159, PTX2, SAP
Protein Interaction Partner: COPS5, GK, HES1, GRB2, GOT2, FCGR3B, FCGR2B, CALU, TG, LAMA1, FCGR1A, FCGR3A, FN1, CRP, C4BPA, C1QA, COL4A1, APCS,
Protein Size: 223

Poids moléculaire: 25 kDa

ID gène: 325

NCBI Accession: NM_001639, NP_001630

UniProt: P02743