Nanog anticorps (Middle Region)

N° du produit ABIN2777175

Cet anticorps Lapin Polyclonal détecte spécifiquement Nanog dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Mouton, Chévre, Cheval, Cobaye et Lapin. Il a été cité dans 4+ publications.

Aperçu rapide pour Nanog anticorps (Middle Region) (ABIN2777175)

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Mouton, Chévre, Cheval, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nanog est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Nanog anticorps

Épitope: Middle Region

Fonction: NANOG Antibody - middle region

Séquence: SYKQVKTWFQ NQRMKSKRWQ KNNWPKNSNG VTQKASAPTY PSLYSSYHQG

Homologie: Cow: 86%, Dog: 93%, Goat: 86%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 92%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against NANOG. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NANOG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30891-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Nanog (ABIN2777175)

Kallas, Pook, Maimets, Zimmermann, Maimets: "Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells." dans: PLoS ONE, Vol. 6, Issue 4, pp. e19114, (2011) (PubMed).

Yang, Atkinson, Vilella, Lloret, Armstrong, Mann, Lako: "Opposing putative roles for canonical and noncanonical NF?B signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells." dans: Stem cells (Dayton, Ohio), Vol. 28, Issue 11, pp. 1970-80, (2010) (PubMed).

Neganova, Zhang, Atkinson, Lako: "Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells." dans: Oncogene, Vol. 28, Issue 1, pp. 20-30, (2009) (PubMed).

Maimets, Neganova, Armstrong, Lako: "Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells." dans: Oncogene, Vol. 27, Issue 40, pp. 5277-87, (2008) (PubMed).

Détails sur Nanog

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Autre désignation: NANOG

Sujet:

Background Information: NANOG is a new marker for testicular carcinoma in situ and germ cell tumors. Gene knockdown of Nanog promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal.

Gene Name: Nanog homeobox

Alternative Symbols: -

Protein Name: Putative homeobox protein NANOGP8

Poids moléculaire: 34kDa

ID gène: 79923

NCBI Accession: NP_079141

UniProt: Q6NSW7

Pathways: Stem Cell Maintenance