Androgen Receptor anticorps (N-Term)

N° du produit ABIN2777192

Détail du produit anti-Androgen Receptor anticorps

Antigène: Androgen Receptor (AR)

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB)

Séquence: MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against AR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human AR

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 920 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: AR (AR Produits)

Synonymes: anticorps AIS, anticorps DHTR, anticorps HUMARA, anticorps HYSP1, anticorps KD, anticorps NR3C4, anticorps SBMA, anticorps SMAX1, anticorps TFM, anticorps AW320017, anticorps Tfm, anticorps Andr, anticorps AR, anticorps androgen receptor, anticorps AR, anticorps Ar, anticorps ar

Sujet: AR has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Alias Symbols: AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, HYSP1
Protein Interaction Partner: AATF, SPOP, UBC, TSG101, TAF1, EP300, DAPK3, USP12, TTC5, SIRT1, RNF6, MAGEA11, VCP, KIF1A, NSD1, WIPI1, NDE1, NCOA1, REL, SMAD1, WDR77, AR, RANBP9, VHL, SKP2, RNF14, EZH2, BMI1, DCAF6, SUZ12, EED, RNF2, RBL1, PTGES3, NCOA4, SUMO2, CUL2, UXT, TCF4, ACTB,
Protein Size: 920

Poids moléculaire: 99 kDa

ID gène: 367

NCBI Accession: NM_000044, NP_000035

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding