TFAM anticorps (N-Term)

N° du produit ABIN2777277

Détail du produit anti-TFAM anticorps

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Épitope: N-Term

Reactivité: Humain, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Porc, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFAM est non-conjugé

Application: Western Blotting (WB)

Séquence: AKTTELIRRI AQRWRELPDS KKKIYQDAYR AEWQVYKEEI SRFKEQLTPS

Homologie: Cow: 92%, Dog: 83%, Guinea Pig: 75%, Horse: 92%, Human: 100%, Mouse: 75%, Pig: 92%, Rabbit: 83%

Attributs du produit: This is a rabbit polyclonal antibody against Transcription Factor AntibodiesAM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TFAM

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 246 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-TFAM (ABIN2777277)

Ogasawara, Liu, Pelicano, Hammoudi, Croce, Keating, Huang: "Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53." dans: Mitochondrion, Vol. 31, pp. 33-39, (2016) (PubMed).

Kemper, Stirone, Krause, Duckles, Procaccio: "Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection." dans: European journal of pharmacology, Vol. 723, pp. 322-9, (2014) (PubMed).

Vettor, Valerio, Ragni, Trevellin, Granzotto, Olivieri, Tedesco, Ruocco, Fossati, Fabris, Serra, Carruba, Nisoli: "Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism." dans: American journal of physiology. Endocrinology and metabolism, Vol. 306, Issue 5, pp. E519-28, (2014) (PubMed).

Kemper, Zhao, Duckles, Krause: "Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 1, pp. 122-8, (2013) (PubMed).

Teodoro, Duarte, Gomes, Varela, Peixoto, Rolo, Palmeira: "Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation." dans: Mitochondrion, Vol. 13, Issue 6, pp. 637-46, (2013) (PubMed).

Miyazaki, Iwasawa, Nakashima, Mori, Shigemoto, Nakamura, Katagiri, Takayanagi, Tanaka: "Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption." dans: The Journal of biological chemistry, Vol. 287, Issue 45, pp. 37808-23, (2012) (PubMed).

Lu, Chen, Zhang, Wang, Luo, Huang: "ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction." dans: Cell death & disease, Vol. 3, pp. e422, (2012) (PubMed).

Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." dans: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

Walters, Bjork, Wallace: "Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats." dans: Toxicology, Vol. 264, Issue 1-2, pp. 10-5, (2009) (PubMed).

Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: "Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells." dans: The Journal of biological chemistry, Vol. 283, Issue 45, pp. 30658-67, (2008) (PubMed).

Détails sur TFAM

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Autre désignation: TFAM (TFAM Produits)

Synonymes: anticorps tcf6, anticorps mttf1, anticorps mttfa, anticorps tcf6l1, anticorps tcf6l2, anticorps tcf6l3, anticorps mttfa-A, anticorps xl-mtTFA, anticorps MGC153358, anticorps zgc:153358, anticorps MTTF1, anticorps MTTFA, anticorps TCF6, anticorps TCF6L1, anticorps TCF6L2, anticorps TCF6L3, anticorps AI661103, anticorps Hmgts, anticorps mtTFA, anticorps tsHMG, anticorps Mttfa, anticorps transcription factor A, mitochondrial, anticorps transcription factor A, mitochondrial L homeolog, anticorps TFAM, anticorps tfam.L, anticorps tfam, anticorps Tfam

Sujet: The function remains unknown.This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.
Alias Symbols: TCF6, MtTF1, mtTFA, TCF6L1, TCF6L2, TCF6L3
Protein Interaction Partner: AGTRAP, FBXW11, ARL6IP1, NEDD1, PPP2R1A, GRSF1, UBC, MDM2, SUZ12, EED, PAN2, MYC, FN1, C1QBP, CAND1, COPS5, CUL3, ELAVL1, ICT1, TFB2M, TFB1M, PNP, NRF1,
Protein Size: 246

Poids moléculaire: 29 kDa

ID gène: 7019

NCBI Accession: NM_003201, NP_003192

UniProt: Q00059

Pathways: Chromatin Binding