MXI1 anticorps (Middle Region)

N° du produit ABIN2777279

L’anticorps anti-MXI1 Polyclonal Lapin est utilisé pour la détection de MXI1 dans des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio) et Saccharomyces cerevisiae. Il a été validé pour WB et IHC.

Aperçu rapide pour MXI1 anticorps (Middle Region) (ABIN2777279)

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MXI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MXI1 anticorps

Épitope: Middle Region

Fonction: MXI1 Antibody - middle region

Séquence: LNKAKAHIKK LEEAERKSQH QLENLEREQR FLKWRLEQLQ GPQEMERIRM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MXI1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MXI1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31403-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MXI1

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Autre désignation: MXI1

Sujet:

Background Information: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors.Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

Gene Name: MAX interactor 1

Alternative Symbols: MXI, MAD2, MXD2, bHLHc11

Protein Name: Max-interacting protein 1

Poids moléculaire: 26kDa

ID gène: 4601

NCBI Accession: NP_569157

UniProt: P50539

Pathways: Maintenance of Protein Location