AIRE anticorps (Middle Region)

N° du produit ABIN486887

L’anticorps anti-AIRE Polyclonal Lapin est utilisé pour la détection de AIRE dans des échantillons de Humain, Rat, Chien, Cheval et Cobaye. Il a été validé pour WB.

Aperçu rapide pour AIRE anticorps (Middle Region) (ABIN486887)

Antigène: AIRE (Autoimmune Regulator (AIRE))

Reactivité: Humain, Rat, Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIRE est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AIRE anticorps

Épitope: Middle Region

Séquence: GGSKKCIQVG GEFYTPSKFE DSGSGKNKAR SSSGPKPLVR AKGAQGAAPG

Homologie: Dog: 77%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human AIRE

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 545 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur AIRE

Antigène: AIRE (Autoimmune Regulator (AIRE))

Autre désignation: AIRE

Sujet: The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
Protein Size: 545

Poids moléculaire: 58 kDa

ID gène: 326

NCBI Accession: NM_000383, NP_000374

UniProt: O43918

Pathways: Chromatin Binding