SOX18 anticorps (Middle Region)

N° du produit ABIN2777725

Détail du produit anti-SOX18 anticorps

Antigène: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOX18 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: RTAPPAAPLA GLYYGTLGTP GPYPGPLSPP PEAPPLESAE PLGPAADLWA

Homologie: Cow: 86%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SOX18. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SOX18

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 384 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SOX18 (ABIN2777725)

Park, Lee, Park, Choi, Lee, Song, Hwang, Hong, Nakaoka, Makinen, Kim, Alitalo, Hong, Koh: "Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity." dans: The Journal of clinical investigation, Vol. 124, Issue 9, pp. 3960-74, (2014) (PubMed).

Deng, Atri, Eichmann, Simons: "Endothelial ERK signaling controls lymphatic fate specification." dans: The Journal of clinical investigation, Vol. 123, Issue 3, pp. 1202-15, (2013) (PubMed).

Duong, Proulx, Luciani, Leroux, Detmar, Koopman, Francois: "Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice." dans: Cancer research, Vol. 72, Issue 12, pp. 3105-14, (2012) (PubMed).

Détails sur SOX18

Antigène: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Autre désignation: SOX18 (SOX18 Produits)

Synonymes: anticorps HLTS, anticorps AI385749, anticorps Ra, anticorps Ragl, anticorps sox18, anticorps xSox18alpha, anticorps xSox18beta, anticorps xsox18, anticorps SRY-box 18, anticorps SRY (sex determining region Y)-box 18, anticorps SRY box 18, anticorps SRY-box 18 S homeolog, anticorps SRY-box 18 L homeolog, anticorps SRY box 1, anticorps SOX18, anticorps Sox18, anticorps sox18.S, anticorps sox18.L, anticorps Sox1

Sujet: SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
Alias Symbols: HLTS
Protein Interaction Partner: GKAP1, MECP2, MEF2C, HMGB1,
Protein Size: 384

Poids moléculaire: 41 kDa

ID gène: 54345

NCBI Accession: NM_018419, NP_060889

UniProt: P35713