PRDM16 anticorps (Middle Region)

N° du produit ABIN2777828

Cet anticorps Lapin Polyclonal détecte spécifiquement PRDM16 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Cobaye, Cheval, Boeuf (Vache) et Porc.

Aperçu rapide pour PRDM16 anticorps (Middle Region) (ABIN2777828)

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Reactivité: Humain, Rat, Cobaye, Cheval, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM16 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PRDM16 anticorps

Épitope: Middle Region

Fonction: PRDM16 Antibody - middle region

Séquence: LNHTQDAKLP SPLGNPALPL VSAVSNSSQG TTAAAGPEEK FESRLEDSCV

Homologie: Cow: 92%, Dog: 77%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 92%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against PRDM16. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRDM16

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33260-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRDM16

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Autre désignation: PRDM16

Sujet:

Background Information: The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: PR domain containing 16

Alternative Symbols: MEL1, KMT8F, LVNC8, PFM13, CMD1LL

Protein Name: PR domain zinc finger protein 16

Poids moléculaire: 140kDa

ID gène: 63976

NCBI Accession: NP_071397

UniProt: Q9HAZ2

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation