SNAIL anticorps (N-Term)

N° du produit ABIN2777858

Cet anticorps Lapin Polyclonal détecte spécifiquement SNAIL dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat et Cobaye et a été mentionné dans 4+ publications.

Aperçu rapide pour SNAIL anticorps (N-Term) (ABIN2777858)

Antigène: SNAIL (SNAI1)

Reactivité: Humain, Souris, Rat, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SNAIL anticorps

Épitope: N-Term

Séquence: MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL

Homologie: Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SNAI1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SNAI1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 264 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SNAIL (ABIN2777858)

He, Lu, Hu, Zhang, Qin, Wang, Xing, Xi, Wang: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." dans: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).

Sihto, Lundin, Lundin, Lehtimäki, Ristimäki, Holli, Sailas, Kataja, Turpeenniemi-Hujanen, Isola, Heikkilä, Joensuu: "Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study." dans: Breast cancer research : BCR, Vol. 13, Issue 5, pp. R87, (2012) (PubMed).

Surati, Robinson, Nandi, Faoro, Demchuk, Rolle, Kanteti, Ferguson, Hasina, Gangadhar, Salama, Arif, Kirchner, Mendonca, Campbell, Limvorasak, Villaflor, Hensing, Krausz, Vokes, Husain, Ferguson et al.: "Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. ..." dans: Journal of clinical bioinformatics, Vol. 1, Issue 8, pp. 1-11, (2011) (PubMed).

Wang, Quah, Dong, Manser, Tang, Zeng: "PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition." dans: Cancer research, Vol. 67, Issue 7, pp. 2922-6, (2007) (PubMed).

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI1

Sujet: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.
Alias Symbols: SNA, SNAH, SNAIL, SLUGH2, SNAIL1, dJ710H13.1
Protein Interaction Partner: MTUS2, KRT31, TRIM23, ACTN2, MID2, NOTCH2NL, KRTAP10-3, KRT40, FBXL5, EZH2, RNF2, RING1, LATS2, UBC, BTRC, TP53, MDM2, GSK3B, HDAC1, CHD4, KDM1A, HDAC3, HDAC2, RCOR1, FBXL14, NOTCH1, HIST1H3A, EGR1, AJUBA, Sin3a, HOXD4, SUZ12, CTDSP1, CTDSPL, CTDSP2, QRIC
Protein Size: 264

Poids moléculaire: 29 kDa

ID gène: 6615

NCBI Accession: NM_005985, NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling