ATXN7 anticorps (Middle Region)

N° du produit ABIN2777891

Détail du produit anti-ATXN7 anticorps

Antigène: ATXN7 (Ataxin 7 (ATXN7))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATXN7 est non-conjugé

Application: Western Blotting (WB)

Séquence: TRSLTCKTHS LTQRRAVQGR RKRFDVLLAE HKNKTREKEL IRHPDSQQPP

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against ATXN7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ATXN7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 892 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ATXN7 (ABIN2777891)

Mu, Lin, Chen, Sung, Bai, Jow: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." dans: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).

Détails sur ATXN7

Antigène: ATXN7 (Ataxin 7 (ATXN7))

Autre désignation: ATXN7 (ATXN7 Produits)

Synonymes: anticorps MGC82940, anticorps ADCAII, anticorps OPCA3, anticorps SCA7, anticorps A430107N12Rik, anticorps AI627028, anticorps Sca7, anticorps ataxin-7, anticorps RGD1562692, anticorps ataxin 7 L homeolog, anticorps ataxin 7, anticorps atxn7.L, anticorps atxn7, anticorps ATXN7, anticorps Atxn7

Sujet: ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Alias Symbols: ADCAII, OPCA3, SCA7
Protein Interaction Partner: VCP, USP22, PICK1, TP53BP2, RAD23A, ATXN7L3, ENY2, PIAS1, SUMO1, UBE2I, SUMO2, KAT2A, AGRN, LRSAM1, ADAM33, CEP70, COG6, TRIM54, CEP72, RNF31, PPP1R12C, CRIM1, TXNDC11, EFEMP2, UBQLN2, CARD10, NOC2L, NUP62, MPRIP, SPRY1, GPRASP1, PNMA1, RABEP1, KALRN, LTB
Protein Size: 892

Poids moléculaire: 95 kDa

ID gène: 6314

NCBI Accession: NM_000333, NP_000324

UniProt: O15265