PARP16 anticorps (Middle Region)

N° du produit ABIN2778107

Il existe 1 publication pour ce produit. L’anticorps anti-PARP16 Polyclonal Lapin est utilisé pour la détection de PARP16 dans des échantillons de Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Porc et Lapin. Il a été validé pour WB et IHC.

Aperçu rapide pour PARP16 anticorps (Middle Region) (ABIN2778107)

Antigène: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP16 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PARP16 anticorps

Épitope: Middle Region

Fonction: PARP16 Antibody - middle region

Séquence: PKYFVVTNNQ LLRVKYLLVY SQKPPKSRAS SQLSWFSSHW FTVMISLYLL

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PARP16

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33752-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PARP16 (ABIN2778107)

Di Paola, Micaroni, Di Tullio, Buccione, Di Girolamo: "PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1." dans: PLoS ONE, Vol. 7, Issue 6, pp. e37352, (2012) (PubMed).

Détails sur PARP16

Antigène: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Autre désignation: PARP16

Sujet:

Background Information: Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Gene Name: Poly (ADP-ribose) polymerase family, member 16

Alternative Symbols: ARTD15, pART15, C15orf30

Protein Name: Mono [ADP-ribose] polymerase PARP16

Poids moléculaire: 36 kDa

ID gène: 54956

NCBI Accession: NP_060321

UniProt: Q8N5Y8