HNRNPD/AUF1 anticorps (C-Term)

N° du produit ABIN2778693

Cet anticorps Lapin Polyclonal détecte spécifiquement HNRNPD/AUF1 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Poisson zèbre (Danio rerio), Porc et Lapin et a été mentionné dans 3+ publications.

Aperçu rapide pour HNRNPD/AUF1 anticorps (C-Term) (ABIN2778693)

Antigène: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Poisson zèbre (Danio rerio), Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPD/AUF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HNRNPD/AUF1 anticorps

Épitope: C-Term

Séquence: YGYNSQGYGG YGGYDYTGYN NYYGYGDYSN QQSGYGKVSR RGGHQNSYKP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against HNRPD. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 355 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HNRNPD/AUF1 (ABIN2778693)

Subramaniam, Ooi, Hui: "Transcriptional down-regulation of IGFBP-3 in human hepatocellular carcinoma cells is mediated by the binding of TIA-1 to its AT-rich element in the 3'-untranslated region." dans: Cancer letters, Vol. 297, Issue 2, pp. 259-68, (2010) (PubMed).

Kang, Chen, Kim, Kang, Park: "Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells." dans: Oncogene, Vol. 28, Issue 4, pp. 565-74, (2009) (PubMed).

Dhakras, Hajarnis, Taylor, Curthoys: "cAMP-dependent stabilization of phosphoenolpyruvate carboxykinase mRNA in LLC-PK1-F+ kidney cells." dans: American journal of physiology. Renal physiology, Vol. 290, Issue 2, pp. F313-8, (2006) (PubMed).

Détails sur HNRNPD/AUF1

Antigène: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Autre désignation: HNRPD

Sujet: HNRPD belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
Alias Symbols: P37, AUF1, AUF1A, HNRPD, hnRNPD0
Protein Interaction Partner: NCL, FUS, KAT2B, SUMO2, SUMO3, IVNS1ABP, STAU1, UBC, NEDD8, MDM2, ERG, RPA3, RPA2, RPA1, ASB2, EED, rev, ERI1, RPS12, PTBP1, PAFAH1B3, WNK1, IPO11, EIF3K, KHSRP, DENR, PARK2, DGCR2, GTF3C3, PDLIM7, UQCRC1, HIRA, SNAPC4, SLC3A2, SDF2, COG7, TMEM261, ABCC10
Protein Size: 355

Poids moléculaire: 39 kDa

ID gène: 3184

NCBI Accession: NM_031370, NP_112738

UniProt: Q14103