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Aconitase 1 anticorps (N-Term)

ACO1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc, Chien, Cobaye, Cheval WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2778793
  • Antigène Voir toutes Aconitase 1 (ACO1) Anticorps
    Aconitase 1 (ACO1)
    Épitope
    • 20
    • 18
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 100
    • 44
    • 39
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc, Chien, Cobaye, Cheval
    Hôte
    • 104
    • 3
    • 1
    Lapin
    Clonalité
    • 106
    • 2
    Polyclonal
    Conjugué
    • 50
    • 12
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Cet anticorp Aconitase 1 est non-conjugé
    Application
    • 94
    • 39
    • 34
    • 26
    • 26
    • 20
    • 11
    • 11
    • 9
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC
    Homologie
    Cow: 100%, Dog: 93%, Guinea Pig: 91%, Horse: 92%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against ACO1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human ACO1
    Top Product
    Discover our top product ACO1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 889 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Aconitase 1 (ACO1)
    Autre désignation
    ACO1 (ACO1 Produits)
    Synonymes
    anticorps ACONS, anticorps IREB1, anticorps IREBP, anticorps IREBP1, anticorps IRP1, anticorps Acon1, anticorps Ratireb, anticorps ratireb, anticorps Aco1, anticorps AI256519, anticorps Aco-1, anticorps Irebp, anticorps Irp1, anticorps aconitase 1, anticorps aconitase 1, soluble, anticorps aconitase 1 L homeolog, anticorps ACO1, anticorps Aco1, anticorps aco1.L
    Sujet
    ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
    Alias Symbols: IRP1, ACONS, IREB1, IREBP, IREBP1
    Protein Interaction Partner: UBC, FBXL5, DCPS, STRAP, FUBP1, PSMG1, HIST1H2AB, LGALS1, CTPS1, C12orf57, APP, AKT1,
    Protein Size: 889
    Poids moléculaire
    98 kDa
    ID gène
    48
    NCBI Accession
    NM_002197, NP_002188
    UniProt
    P28271
    Pathways
    Transition Metal Ion Homeostasis
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