SSB anticorps (N-Term)

N° du produit ABIN2778846

Détail du produit anti-SSB anticorps

Antigène: SSB (Sjogren Syndrome Antigen B (SSB))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SSB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: ISEDKTKIRR SPSKPLPEVT DEYKNDVKNR SVYIKGFPTD ATLDDIKEWL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SSB. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SSB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 408 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SSB (ABIN2778846)

Teplova, Yuan, Phan, Malinina, Ilin, Teplov, Patel: "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen." dans: Molecular cell, Vol. 21, Issue 1, pp. 75-85, (2006) (PubMed).

Détails sur SSB

Antigène: SSB (Sjogren Syndrome Antigen B (SSB))

Autre désignation: SSB (SSB Produits)

Synonymes: anticorps LARP3, anticorps La, anticorps lab1, anticorps larp3, anticorps ssb, anticorps Mt-SSB, anticorps MtSSB, anticorps Ssbp1, anticorps SS-B, anticorps laa-a, anticorps ssb-a, anticorps ssb-b, anticorps wu:fb17f11, anticorps zgc:55588, anticorps Sjogren syndrome antigen B, anticorps Sjogren syndrome antigen B L homeolog, anticorps single stranded DNA binding protein 1, anticorps Sjogren syndrome antigen B S homeolog, anticorps Sjogren syndrome antigen B (autoantigen La), anticorps SSB, anticorps ssb.L, anticorps SSBP1, anticorps Ssb, anticorps ssb.S, anticorps ssb

Sujet: SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE, MIM 152700) (Teplova et al., 2006).[supplied by OMIM].
Alias Symbols: La, LARP3
Protein Interaction Partner: HUWE1, UBC, MDM2, LIN28A, BMI1, SUZ12, RNF2, rev, NPLOC4, DNM1L, UBA2, ANP32A, VBP1, RABGGTA, PPP2CA, KARS, CTTN, TARDBP, SOX2, HMGA1, ARFGEF1, NCL, GZMH, CSNK2B, CSNK2A1, HCVgp1, CBX6, SPIB, IL7R, IFIT3, FN1, SMURF1, BARD1, PAXIP1, APP, TROVE2, XIAP, CAN
Protein Size: 408

Poids moléculaire: 45 kDa

ID gène: 6741

NCBI Accession: NM_003142, NP_003133

UniProt: P05455