XPO1 anticorps (C-Term)

N° du produit ABIN2778849

Cet anticorps anti-XPO1 est un anticorps Lapin Polyclonal détectant XPO1 dans WB et IHC. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Poisson zèbre (Danio rerio), Lapin, Porc et Saccharomyces cerevisiae. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour XPO1 anticorps (C-Term) (ABIN2778849)

Antigène: XPO1 (Exportin 1 (XPO1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Poisson zèbre (Danio rerio), Lapin, Porc, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-XPO1 anticorps

Épitope: C-Term

Séquence: NKLGGHITAE IPQIFDAVFE CTLNMINKDF EEYPEHRTNF FLLLQAVNSH

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against XPO1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1071 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-XPO1 (ABIN2778849)

Kalita, Kapinos, Zheng, Rencurel, Zilman, Lim: "Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage." dans: The Journal of cell biology, Vol. 221, Issue 3, (2022) (PubMed).

Détails sur XPO1

Antigène: XPO1 (Exportin 1 (XPO1))

Autre désignation: XPO1

Sujet: XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CRM1, DKFZp686B1823, emb, exp1
Protein Interaction Partner: ABL1, UBC, HUWE1, ELAVL1, KEAP1, SUMO2, SUMO3, USP16, STAU1, CDC37L1, RNF2, rev, TUBB, SCPEP1, CAMK1D, DCPS, HSPA1L, HNRNPK, GNAI3, EEF2, CAPN2, TWF2, FERMT2, UBA3, NAE1, STK24, YWHAH, YWHAE, VCL, TUFM, PCYT2, PPP5C, PPP1CA, EGFR, LOC366310, CLN5, CLN3, S
Protein Size: 1071

Poids moléculaire: 123 kDa

ID gène: 7514

NCBI Accession: NM_003400, NP_003391

UniProt: O14980

Pathways: M Phase