PCBP2 anticorps (Poly(rC) Binding Protein 2) (Middle Region)

Details for Product anti-PCBP2 Antibody No. ABIN2778923
Antigène
  • HNRNPE2
  • HNRPE2
  • hnRNP-E2
  • AW412548
  • Hnrpx
  • alphaCP-2
  • PCBP3
  • fb36h02
  • wu:fb36h02
  • zgc:55964
  • PCBP2
  • poly(rC) binding protein 2
  • poly(rC) binding protein 2 L homeolog
  • PCBP2
  • Pcbp2
  • pcbp2
  • pcbp2.L
Épitope
Middle Region
6
6
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Cobaye, Cheval, Humain, Souris, Rat (Rattus)
63
32
29
5
5
4
3
3
2
2
2
1
1
1
1
Hôte
Lapin
49
14
Clonalité
Polyclonal
Conjugué
Cet anticorp PCBP2 est non-conjugé
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
51
26
24
19
7
6
4
4
3
1
1
1
Options
Immunogène The immunogen is a synthetic peptide directed towards the middle region of human PCBP2
Séquence VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ
Homologie Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
Attributs du produit This is a rabbit polyclonal antibody against PCBP2. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Plasmids, Primers & others Plasmids, Primers & others PCBP2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation PCBP2 (PCBP2 Antibody Extrait)
Sujet PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.
Alias Symbols: HNRPE2, hnRNP-E2
Protein Interaction Partner: FUS, HUWE1, UBC, SNRPA, SUMO2, SUMO3, CEP250, MDM2, EED, TARDBP, ADRB2, IGSF8, HMGA1, CD81, HMGA2, WDR83, SLU7, CASK, UBL4A, VCAM1, PCBP2, NOS2, ITGA4, FN1, BRCA1, PRPF40A, SF3B2, NKAP, WDR77, PAXIP1, BARD1, PPIB, EEF1A1, FBXO6, UBD, PCBP1, QKI, CDK2, COP
Protein Size: 366
Poids moléculaire 40 kDa
ID gène 5094
NCBI Accession NM_005016, NP_005007
UniProt Q6IPF4
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 366 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Image no. 1 for anti-Poly(rC) Binding Protein 2 (PCBP2) (Middle Region) antibody (ABIN2778923) Rabbit Anti-PCBP2 Antibody Paraffin Embedded Tissue: Human Lung Cellular Data: Alveo...
Image no. 2 for anti-Poly(rC) Binding Protein 2 (PCBP2) (Middle Region) antibody (ABIN2778923) WB Suggested Anti-PCBP2 Antibody Titration: 1.25ug/ml Positive Control: Jurkat cel...
Produit citée dans: Lin, Yang, Liu, Tan, Wu, Hu, Jiang, Bao, Yuan, Qiang, Peng, Han: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." dans: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, 2016 (PubMed).

Han, Xin, Zhao, Bao, Lin, Yin, Zhao, Yuan, Qiang, Peng: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." dans: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, 2013 (PubMed).

Background publications Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: "Transcriptome analysis of human gastric cancer." dans: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, 2005 (PubMed).

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