HNRPDL anticorps (C-Term)

N° du produit ABIN2778938

Cet anticorps Lapin Polyclonal détecte spécifiquement HNRPDL dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio) et Lapin et a été mentionné dans 2+ publications.

Aperçu rapide pour HNRPDL anticorps (C-Term) (ABIN2778938)

Antigène: HNRPDL (Heterogeneous Nuclear Ribonucleoprotein D-Like (HNRPDL))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRPDL est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HNRPDL anticorps

Épitope: C-Term

Séquence: YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against HNRPDL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPDL

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 420 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HNRPDL (ABIN2778938)

Li, Johansson, Glahder, Mossberg, Schwartz: "Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs." dans: Nucleic acids research, Vol. 41, Issue 22, pp. 10488-508, (2013) (PubMed).

Anderson, Lin, Xiao, Stoilov, Burge, Black: "The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B." dans: RNA (New York, N.Y.), Vol. 18, Issue 5, pp. 1041-9, (2012) (PubMed).

Détails sur HNRPDL

Antigène: HNRPDL (Heterogeneous Nuclear Ribonucleoprotein D-Like (HNRPDL))

Autre désignation: HNRPDL

Sujet: HNRPDL belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. HNRPDL has two RRM domains that bind to RNAs. Two alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein is similar to its family member HNRPD.
Alias Symbols: HNRNP, JKTBP, JKTBP2, laAUF1, HNRPDL
Protein Interaction Partner: SPRTN, SUMO2, SUMO3, UBC, RPA3, RPA2, RPA1, ERG, EED, RNF2, rev, PARK2, FBXO6, TARDBP, HMGA1, ITGA4, IL7R, IFIT3, IFIT2, FN1, CSNK2A1, BARD1, EEF2, EEF1A1, DDX3X, ATP6V1B1, HNRNPA3, WIPF2, RMDN3, MRPS16, UBE2S, LSM14A, RPL36, U2AF2, HNRNPUL1, HNRNPA0, HNR
Protein Size: 420

Poids moléculaire: 46 kDa

ID gène: 9987

NCBI Accession: NM_005463, NP_005454

UniProt: O14979