CPSF4 anticorps (C-Term)

N° du produit ABIN2779005

Cet anticorps anti-CPSF4 est un anticorps Lapin Polyclonal détectant CPSF4 dans WB. Adapté pour Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache) et Lapin.

Aperçu rapide pour CPSF4 anticorps (C-Term) (ABIN2779005)

Antigène: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPSF4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CPSF4 anticorps

Épitope: C-Term

Séquence: SLIQLTSQNS SPNQQRTPQV IGVMQSQNSS AGNRGPRPLE QVTCYKCGEK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CPSF4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 216 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CPSF4

Antigène: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Autre désignation: CPSF4

Sujet: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
Alias Symbols: CPSF30, NAR, NEB1
Protein Interaction Partner: FIP1L1, RBBP6, MEOX2, CLK2, NPM1, MDC1, ECT2, UBC, CSTF2T, RRAGA, CDC73, SLC12A9, MARK3,
Protein Size: 216

Poids moléculaire: 24 kDa

ID gène: 10898

NCBI Accession: NM_001081559

UniProt: O95639