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CPSF4 anticorps (C-Term)

CPSF4 Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779005
  • Antigène Voir toutes CPSF4 Anticorps
    CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
    Épitope
    • 12
    • 7
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 45
    • 13
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 44
    • 1
    Polyclonal
    Conjugué
    • 21
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CPSF4 est non-conjugé
    Application
    • 45
    • 20
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    SLIQLTSQNS SPNQQRTPQV IGVMQSQNSS AGNRGPRPLE QVTCYKCGEK
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against CPSF4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4
    Top Product
    Discover our top product CPSF4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 216 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
    Autre désignation
    CPSF4 (CPSF4 Produits)
    Synonymes
    anticorps cpsf30, anticorps nar, anticorps neb1, anticorps 30kDa, anticorps C79664, anticorps CPSF30, anticorps NAR, anticorps NEB1, anticorps cleavage and polyadenylation specific factor 4, anticorps cleavage and polyadenylation specific factor 4, 30kDa, anticorps cleavage and polyadenylation specific factor 4 S homeolog, anticorps CPSF4, anticorps Cpsf4, anticorps LOC733099, anticorps LOC100360200, anticorps cpsf4.S, anticorps cpsf4
    Sujet
    Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
    Alias Symbols: CPSF30, NAR, NEB1
    Protein Interaction Partner: FIP1L1, RBBP6, MEOX2, CLK2, NPM1, MDC1, ECT2, UBC, CSTF2T, RRAGA, CDC73, SLC12A9, MARK3,
    Protein Size: 216
    Poids moléculaire
    24 kDa
    ID gène
    10898
    NCBI Accession
    NM_001081559
    UniProt
    O95639
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