CPSF4 anticorps (C-Term)
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- Antigène Voir toutes CPSF4 Anticorps
- CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CPSF4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SLIQLTSQNS SPNQQRTPQV IGVMQSQNSS AGNRGPRPLE QVTCYKCGEK
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against CPSF4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4
- Top Product
- Discover our top product CPSF4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 216 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
- Autre désignation
- CPSF4 (CPSF4 Produits)
- Synonymes
- anticorps cpsf30, anticorps nar, anticorps neb1, anticorps 30kDa, anticorps C79664, anticorps CPSF30, anticorps NAR, anticorps NEB1, anticorps cleavage and polyadenylation specific factor 4, anticorps cleavage and polyadenylation specific factor 4, 30kDa, anticorps cleavage and polyadenylation specific factor 4 S homeolog, anticorps CPSF4, anticorps Cpsf4, anticorps LOC733099, anticorps LOC100360200, anticorps cpsf4.S, anticorps cpsf4
- Sujet
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Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
Alias Symbols: CPSF30, NAR, NEB1
Protein Interaction Partner: FIP1L1, RBBP6, MEOX2, CLK2, NPM1, MDC1, ECT2, UBC, CSTF2T, RRAGA, CDC73, SLC12A9, MARK3,
Protein Size: 216 - Poids moléculaire
- 24 kDa
- ID gène
- 10898
- NCBI Accession
- NM_001081559
- UniProt
- O95639
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